1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA-registered facility.

2. Utilizes efficacious evidence-based dosages with optimal ratios of amino acids, nootropics, and pump enhancers to support exercise performance and recovery.

Vitamin B6 pyridoxal 5'-phosphate (PLP)

• Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
• Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
• Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
• May support blood sugar regulation in women with gestational diabetes (40).
• Cofactor for enzymes involved in DNA metabolism (40).

Niacin (Vitamin B3)

• Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
• Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
• Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
• Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
• Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11).
• Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12).
• Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9).
• Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9).
• Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).

Caffeine Anhydrous 

• Optimizes energy, cognitive function, and mental alertness (24).
• Supplementation with caffeine has been shown to acutely enhance exercise performance (24).

L-Citrulline Malate

• Supports cardiovascular health and exercise performance by increasing production of l-arginine (34).
• Increases nitric oxide production, improves exercise performance, and increases blood flow to exercising skeletal muscle (35).
• Supports strength increases, exercise endurance, and recovery (34,35).
• May reduce blood pressure by increasing vascular function (34).

Bioperine 

• Increases absorption of amino acids and curcumin.

Folate (Folic Acid)

• May support proper cell growth and DNA synthesis (65).

Vitamin B-12 (Methylcobalamin)

• Metabolically active, methylated form of Vitamin B12 needed for proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53).
• Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
• May prevent vitamin b-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).

Creatine Monohydrate 

• Optimizes exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47).
• Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (47,50).
• Vital in bioenergetics (metabolic activity) of the brain (50). 
• Fuels CD8 and CD4 T- cell mediated immunity (immune cells) in cancer tissue (48,49).
• Supports cognition and focus via replenishment of cerebral storage of creatine (creatine in the brain) (50).
• Supports cognitive health in brain creatine deficiency associated neurodegenerative diseases (50).
• Supports cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (50).

N-Acetyl Tyrosine

• Supports memory, cognitive flexibility, executive function of the brain, and convergent thinking (60).
• Precursor to dopamine and is vital for dopamine synthesis in the brain (60).
• Supports cognitive function in individuals with high amounts of stress and anxiety (60,61).
• Increases dopamine levels in highly stressed individuals (60).

Choline Bitrate

• Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63).
• Serves as a methyl donor and as a precursor for production of cell membranes (62).
• Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system mediated immune responses (α7nAchR) (64). 
• Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62).
• Reduces concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62).

DMAE Bitrate

• Increases acetylcholine levels in the brain.

L-Theanine

• Unique non-protein amino acid found in green tea (Camellia sinensis) (53).
• Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (53).
• Aids as an antidepressant due to partial antagonism for the N-methyl-D-aspartate receptor manifesting its cognitive optimizing effects (53).
• Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (54).

Bacopa Monnieri 

• Supports cognitive function, memory, alertness, and aids as an anti-stress agent (57).
• May combat inflammatory conditions such as asthma, bronchitis, dropsy, and rheumatism (56,59).
• Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (58,59,).
• Promising candidate for the development of novel therapeutics that target neuroinflammation and have the potential for treating a wide range of CNS disorders including Alzheimer's disease, depression, and schizophrenia (59).

• 24. Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
• 33. Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
• 34. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340
• 35. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002
• 38. Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways. Molecular aspects of medicine, 53, 10–27. https://doi.org/10.1016/j.mam.2016.08.001
• 39. Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in food and nutrition research, 83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004
• 40. Mascolo, E., & Vernì, F. (2020). Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms. International journal of molecular sciences, 21(10), 3669. https://doi.org/10.3390/ijms21103669
• 47. Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. doi:10.1186/s12970-017-0173-z
• 48. Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y. C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., To, A., & Yang, L. (2019). Creatine uptake regulates CD8 T cell antitumor immunity. The Journal of experimental medicine, 216(12), 2869–2882. https://doi.org/10.1084/jem.20182044
• 49. Kazak, L., & Cohen, P. (2020). Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature reviews. Endocrinology, 16(8), 421–436. https://doi.org/10.1038/s41574-020-0365-5
• 50. Ebrahimi, K., Jourkesh, M., Sadigh-Eteghad, S., Stannard, S. R., Earnest, C. P., Ramsbottom, R., Antonio, J., & Navin, K. H. (2020). Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer's Diseases. Diseases (Basel, Switzerland), 8(2), 18. https://doi.org/10.3390/diseases8020018
• 51. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
• 52. Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill--a review. Anaesthesia and intensive care, 44(4), 447–452. https://doi.org/10.1177/0310057X1604400410
• 53. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency - A 21st century perspective. Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
• 54. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
• 55. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
• 56. Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. Journal of ethnopharmacology, 197, 92–100. https://doi.org/10.1016/j.jep.2016.07.073
• 57. Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528–535. https://doi.org/10.1016/j.jep.2013.11.008
• 58. Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019). Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst - A review on its mechanistic aspects. Complementary therapies in medicine, 44, 68–82. https://doi.org/10.1016/j.ctim.2019.03.016
• 59. Lurie DI CJ. The role of bacopa monnieri in inflammatory and neurodegenerative diseases. In: Motohashi N, editor. Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits. Nova Science Publishers; New York, USA: 2015a. pp. 27–61. [Google Scholar]
• 60. Hoffer, L. J., Sher, K., Saboohi, F., Bernier, P., MacNamara, E. M., & Rinzler, D. (2003). N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition. JPEN. Journal of parenteral and enteral nutrition, 27(6), 419–422. https://doi.org/10.1177/0148607103027006419
• 62. Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019). Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell, 18(6), e13037. https://doi.org/10.1111/acel.13037
• 63 Jadavji, N. M., Emmerson, J. T., MacFarlane, A. J., Willmore, W. G., & Smith, P. D. (2017). B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of disease, 103, 89–100. https://doi.org/10.1016/j.nbd.2017.04.001
• 64. Jacobson, S. W., Carter, R. C., Molteno, C. D., Stanton, M. E., Herbert, J. S., Lindinger, N. M., Lewis, C. E., Dodge, N. C., Hoyme, H. E., Zeisel, S. H., Meintjes, E. M., Duggan, C. P., & Jacobson, J. L. (2018). Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcoholism, clinical and experimental research, 42(7), 1327–1341. https://doi.org/10.1111/acer.13769
• 65. Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., & Raiten, D. J. (2015). Biomarkers of Nutrition for Development-Folate Review. The Journal of nutrition, 145(7), 1636S–1680S. https://doi.org/10.3945/jn.114.206599

Warning: For use by healthy adults only, not recommended for persons under the age of 18. Do not use if you are pregnant or nursing. Seek advice from a healthcare professional before taking if you have any preexisting medical condition to ensure it is safe to take this product. In case of accidental overdose, contact a poison control center immediately.